The series, depicted by state of the art CGI techniques, and applying the laws of life on Earth to the rest of the galaxy, blends fact with science fiction and conceptualizes what alien life might be like on other planets.
In the prologue, astronomer Didier Queloz makes an appearance to discuss the discoveries of exoplanets and how they are analyzed in the real world. In Episode 1, the fictional world imagined is Atlas, a world with higher gravity than Earth and a thicker atmosphere leading to airborne creatures. In explaining the aliens of Atlas, the episode also explores the handicap principle in insects, and shows a rehabilitative form of falconry as captive falcons are trained to live in the wild.

The season 8 of Space Deepest Secrets shares the stories of deep-space explorers who are risking their careers, and even their lives, to lead humanity to worlds yet to be seen.
In the first episode, astronomers are laying the groundwork to locate a new planet for the human race to inhabit, and the more alien worlds they discover and encounter, the more they unmask the mysterious and truly destructive nature of the cosmos.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Is God worshipped in other worlds, across the cosmos? How might alien deities differ from our own? The answer may lie buried on Earth. Animal behaviorists are testing elephants and finding them capable of having spiritual thoughts. Artificial intelligence researchers are building enlightened robots that contemplate the divine. Meanwhile, cosmologists are looking for universal equations that could replace God. Have advanced aliens discovered everything there is to know about the universe? Or are they looking to a higher power for answers?

NASA's brand-new Mars rover is on the hunt for alien life, and with the help of cutting-edge engineering, scientists embark on a search for fossilized remains, which might prove the Red Planet was once home to a vast ocean and extraterrestrial life. Perseverance carries seven scientific instruments to study the Martian surface at Jezero crater. It carries several cameras and two microphones. The rover is accompanied by the helicopter Ingenuity, which will help Perseverance to scout for locations to study.

Humans have long gazed up at the night sky, wondering whether other lifeforms and intelligences could be thriving on worlds far beyond our own. But over the last few decades, ultra-sensitive telescopes and dogged detective work have transformed alien planet-hunting from science fiction into hard fact. We expected to find worlds similar to the planets in our own solar system, but we instead discovered a riot of exotic worlds. Vivid animation based on data from the most successful planet hunter of them all, the Kepler space telescope, brings these worlds into view: puffy planets with the density of polystyrene, unstable worlds orbiting two suns and 1,000-degree, broiling gas giants with skies whipped into titanic winds.
But perhaps the most startling discovery was the number of worlds that may be contenders for a second Earth, at the right distance from their sun to have that ingredient so crucial for life as we know it, liquid water. Amongst them, we witness the most tantalizing discovery of all: a so-called ‘super-Earth’, situated in the Goldilocks zone - the area just the right distance from a sun to potentially support life - and with the faint signal of water in its atmosphere.