Intrepid adventurer Michael Palin travels through Pakistan's North-West Frontier Province, starting on the Khyber Pass and ending five miles from K2 on the Pakistan/China border. He passes through Darra, visits a street dentist in Peshawar, goes bull racing with a Pakistani aristocrat and is almost trampled to death, and finally crosses over the Lowari Pass into the buffer state of Chitral.

Following the Yangtze along Tiger Leaping Gorge into Yunnan in China, Palin reaches the easternmost end of the Himalayas. He gets a medical check-up before exploring medieval Lijiang with the director of the local orchestra. Heading over Myanmar to Nagaland in India he rides the steam train to Tipong Coalmine. In Assam he rides an elephant and then stays in a strange monastery.

Travelling from K2 in Pakistan to Ladakh in India. It is a short distance as the crow flies but, due to politics, a huge loop. He passes through the Sikh city of Amritsar, with its Golden Temple, and through Shimla with its Vice Regal Lodge, Gaiety Theatre and cosy half-timbered tea-houses. He then meets the 14th Dalai Lama in Dharamsala, where the Tibetan government is in exile.

During a Gurkha recruitment Palin is disturbed by Maoist insurgents, but survives to suffer as he climbs to 15,000 feet and sees the majesty of Annapurna Sanctuary. In Kathmandu he is blessed by the Nepalese king before meeting some holy men. Crossing into Tibet, he meets his first yaks at the highest monastery in the world, before heading up the Rongbuk glacier towards the summit of Everest.

Leaving Everest base camp to take the high road to Lhasa to see what the Chinese have done to Tibet. He sees that religion is once again tolerated, while the old Tibetan centre of the city is being replaced with modern Chinese shopping malls and nightclubs. Following the pilgrims to the holy Namtso Lake, he gets warm in a hot spring before learning how to milk a yak with a nomad family.

In Bhutan, Palin finds himself back in the land of yaks for a last look at the high Himalaya. Trekking to Chomolhari base camp he meets a nomad with a penchant for yak songs before heading down to Paro to witness the Buddhist festival or Tsechu. In a bar in Thimphu, he discusses reincarnation and the pursuit of happiness with Benji and Khendum, two of the king's cousins, and en route to Bangladesh is taken by Benji to see the rare black-neck cranes. On his journey south through Bangladesh, Michael visits the ship-breaking beaches of Chittagong and grid-locked Dhaka. He meets a man who made a fortune in Birmingham in the poultry business, and a woman who lends money only to women. On a 1920s paddle steamer he is serenaded with the words of Bengal's Shakespeare, and he completes his epic Himalayan journey aboard a fishing boat that carries him out into the Bay of Bengal and a westering sun.