The fourth episode sees host Neil deGrasse Tyson exploring our eternal quest to end hunger and honoring Nikolai Ivanovic Vavilov, pioneer of modern plant breeding, who risked his life for a discovery that would change the history of science. Vavilov's story is marked by both the tenacity and creativity and is particularly tragic. Interwoven into Vavilov's somber narrative are warnings and treatments of science and its ethical implications, especially when science itself comes under attack from political forces.

When Homo sapiens, which means 'wise ones,' discovered and controlled fire hundreds of thousands of years ago, everything changed. Fire allowed us to cook food and heat dwellings, and it served as a focal point for storytelling and sharing cultural identity among community members. We don't yet have established parameters for what it means to be 'distinctly human,' It would seem the only thing that separates us from other animals, Neil deGrasse Tyson ponders, is our neurotic need to feel 'special'. Against the backdrop of the Halls of Extinction, Tyson insists that there must be a clear distinction between ourselves and animals that justifies our eating them, wearing them and even bringing an end to their species.
From the birth of the devil in ancient Persia to a searing story of saintliness among macaque monkeys, this episode is an exploration of human potential for change. It concludes with the story of how one of history's greatest monsters was transformed into one of its shining lights.

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about Covid-19 and the pandemic it has created. Michael visits the UK government's high-security laboratory Porton Down, where vaccines are being tested. He also uncovers what the experience of the 2002 SARs epidemic reveals about this one. Both were caused by coronaviruses, but certain key changes to today's virus have allowed it to infect the world, where SARs was contained.

The third episode looks at anxiety and explores why it is so common. It talks to neuroscientists who explain the physiological and evolutionary basis of anxiety. Although it can help animals escape predators, anxiety can cause serious problems for human beings. It talks to sufferers of anxiety and examines the different types of anxiety people can feel. It also looks at how social media can cause anxiety.

A fifth of the land on our planet is covered by desert. Deserts may appear to be barren and empty, but they are of crucial importance to life. For those that can overcome their challenges they provide a vital refuge. The Grasslands are one of our planet's most productive landscapes. They support the greatest aggregations of large animals on Earth. Cameras follow desert elephants seeking sustenance, bison roaming North American grasslands and caterpillars living the good life underground.

It's Valentine's Day and Maddi steps out on her first ever date with a romantic man. Kelvin works with a relationship specialist and puts his dating skills to the test. Michael is overwhelmed when he meets the woman of his dreams.