Nearly half a million years ago, the most advanced human yet roams Europe. Strong and powerful, Homo heidelbergensis are fierce hunters, use sophisticated tools and live in close-knit family groups. Over 200,000 years they become split into two populations by extremes of weather and environment and evolve separately into two very different species. In the North are the Neanderthals, whose physical power and resilience is the key to surviving in ice age Northern Europe. About 140,000 years ago, Africa is in the grip of a devastating drought, and something remarkable has happened to the descendants of heidelbergensis who live there. The combination of environment and chance has bred in them a unique ability that will change the course of human history. It will be this small band of southern survivors, perhaps numbering just a few tens of thousands, who will come to dominate the world and be known as Homo sapiens.

The first episode looks at how birds first took to the skies in the wake of the insects. It begins in Mexico, where Sir Attenborough observes bats being outmanoeuvred by a red-tailed hawk. Pterosaurs were the birds' forerunners, some 150 million years after dragonflies developed the means of flight, but eventually went extinct together with the dinosaurs. Birds had by then already evolved from early forms like archaeopteryx, the first creature to possess feathers. Its ancestry can be traced through reptiles, and some current species, such as the flying lizard, possibly show paths this evolution may have taken." One of the biggest birds to have ever existed was the terror bird, which proliferated after dinosaurs vanished and stood up to 2.5 metres tall. By comparison, the ostrich, while not closely related, is the largest and heaviest living bird. It was probably the evasion of predators that drove most birds into the air, so their flightless cousins evolved because they had few enemies. Accordingly, such species are more likely to be found on islands, and Sir Attenborough visits New Zealand to observe its great variety, most especially the kiwi. Also depicted is the moa, another huge creature that is now gone. The takahē is extremely rare, and high in the mountains of New Zealand, Sir Attenborough discovers one from a population of only 40 pairs. Finally, another example on the brink of extinction is the kakapo, which at one point numbered only 61 individuals. A male is heard calling — an immensely amplified deep note that can be heard at great distances from its nest.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

The idea of intelligence is explored in the concepts of computers (using bits as their basic units of information), whales (in their songs and their disruptions by human activities), DNA, the human brain (the evolution of the brain stem, frontal lobes, neurons, cerebral hemispheres, and corpus callosum under the Triune Brain Model), and man-made structures for collective intelligence (cities, libraries, books, computers, and satellites). The episode ends with speculation on alien intelligence and the information conveyed on the Voyager Golden Record.

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.

The final part reveals how our knowledge of cells has brought us to the brink of one of the most important moments in history. Scientists are close to repeating what has happened only once in four billion years - the creation of a new life form.