We can't compare anything on earth to the biggest things known in space. The Cosmic Web may connect objects in the universe with threads of Dark Matter. The Lyman-alpha blob is a bubble like structure containing countless galaxies--perhaps the biggest object in the entire universe. Regions of radio-emitting gas called "radio lobes" could be even bigger. Then there are super galaxy clusters which are hundreds of galaxies merged together due to cosmic collisions. Discover which is the largest planet, star, star cluster, constellation, black hole, volcano, galaxy, explosions, moon, storm, impact crater and "void" in space.

Beginning with the separation of the fuzzy thinking and pious fraud of astrology from the careful observations of astronomy, Sagan follows the development of astronomical observation. Beginning with constellations and ceremonial calendars (such as those of the Anasazi), the story moves to the debate between Earth and Sun-centered models: Ptolemy and the geocentric worldview, Copernicus' theory, the data-gathering of Tycho Brahe, and the achievements of Johannes Kepler (Kepler's laws of planetary motion and the first science-fiction novel).

Ideas about time and space are explored in the changes that constellations undergo over time, the redshift and blue shift measured in interstellar objects, time dilation in Albert Einstein's theory of relativity, the designs of both Leonardo da Vinci and spacecraft that could travel near light speed, time travel and its hypothetical effects on human history, the origins of the Solar System, the history of life, and the immensity of space. In Cosmos Update, the idea of faster-than-light travel by wormholes (researched by Kip Thorne and shown in Sagan’s novel Contact) is discussed.