A ground-breaking new trial at Imperial College London sees, for the first time ever under controlled conditions, a psychedelic drug tested head-to-head against a standard antidepressant as a treatment for depression. The film follows a pioneering team of scientists and psychotherapists as they compare the effects of psilocybin (the active ingredient of magic mushrooms) with an antidepressant on a small group of participants with clinical depression.
This is scientific research at its most cutting edge. With over seven million people being prescribed antidepressants each year in England alone, this drug trial is an important milestone in understanding a completely different treatment for depression. How do psychedelic drugs measure up against the industry-standard antidepressants that have been popular since the 1990s? The empirical results of the trial are explored alongside the participants’ powerful lived experience.

Trauma is the invisible force that shapes our lives. It shapes the way we live, the way we love and the way we make sense of the world. It is the root of our deepest wounds. Dr. Maté gives us a new vision: a trauma-informed society in which parents, teachers, physicians, policy-makers and legal personnel are not concerned with fixing behaviors, making diagnoses, suppressing symptoms and judging, but seek instead to understand the sources from which troubling behaviors and diseases spring in the wounded human soul.
The interconnected epidemics of anxiety, chronic illness and substance abuse are, according to Dr Gabor Maté, normal. But not in the way you might think. One in five Americans are diagnosed with mental illness in any given year. Suicide is the second most common cause of death in the US for youth aged 15-24, and kills over 700,000 people a year globally and 48,300 in the USA . Drug overdose kills 81,000 in the USA annually. The autoimmunity epidemic affects 24 million people in the USA. What is going on?
“So much of what we call abnormality in this culture is actually normal responses to an abnormal culture. The abnormality does not reside in the pathology of individuals, but in the very culture that drives people into suffering and dysfunction.” — Gabor Maté

Mixing comedy with a thorough investigation of psychedelics, the film explores the pros, cons, science, history, future, pop cultural impact, and cosmic possibilities of hallucinogens. The documentary features comedic tripping stories from A-list actors, comedians, and musicians. Star-studded reenactments and trippy animations bring their surreal hallucinations to life.
'Have a Good Trip' tackles the big questions: Can psychedelics have a powerful role in treating depression, addiction, and helping us confront our own mortality? Are we all made of the same stuff? Is love really all we need? Can trees talk?

Most planets we know of are so hellish, it seems impossible that anything could live. But it's amazing where life can take hold in the Earth. Astrobiologists look for simple single-celled microbes known as extremophiles in places as Danakil Depression, known in Ethiopia as 'The Gateway to Hell.'
In Episode 2, the fictional world is Janus, a planet in such a close orbit than its rotation is locked by the star's gravity and it always shows the same face to its sun. On one side of the planet, it's always daytime, a searing desert. On the other side, it's forever night, a frozen shadowland. Squeezed between the two, a sliver of perpetual twilight. Freezing meltwater flows from the cold side, carving canyons through the landscape. Deep in these canyons lives an extraordinary five-legged creature.

The final episode of this series looks at what happens to the brain when someone uses psychedelic drugs. It looks at how psychedelic drugs may be useful in dealing with anxiety in cancer survivors and serious depression. It explores the history of psychedelics and examines early medical experimentation with the drug. It also discussed why psychedelics were banned and examines how they affect the brain.

Modern headlines are claiming mindfulness may cure anxiety, depression, and a whole host of other health problems. How can this simple practice of watching your own breath change the way your brain works? And can that change your life? The fourth episode of the series looks at the power of mindfulness and meditation. It examines different kinds on meditation (transcendental, dynamic, and religious) and notes that they are different from mindfulness meditation (Satipatthana). Also it talks to neuroscientists who discuss what happens in the brain during meditation.