This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

The terrorist group Boko Haram is responsible for thousands of deaths in Nigeria. Now, the government is determined to drive these militants from the country. But is the hunt for insurgents causing as much harm as it's preventing? Former Navy SEAL and new VICE correspondent Kaj Larsen travels to Nigeria to see what this cat-and-mouse game means for the people caught in the middle of the fight. 'Unnatural Selection': For centuries, scientists have been working to change the genetic traits of plants and animals. Now, the new gene-editing method CRISPR has made that process astonishingly simple - so simple it could easily be used on humans. Isobel Yeung reports from Brazil, Scotland, China and the U.S. on the technological advances that could reshape evolution as we know it.

Memory is the glue that binds our mental lives. Without it, we’d be prisoners of the present, unable to use the lessons of the past to change our future. From our first kiss to where we put our keys, memory represents who we are and how we learn and navigate the world. But how does it work? Neuroscientists using cutting-edge techniques are exploring the precise molecular mechanisms of memory". By studying a range of individuals ranging —from an 11-year-old whiz-kid who remembers every detail of his life to a woman who had memories implanted— scientists have uncovered a provocative idea. For much of human history, memory has been seen as a tape recorder that faithfully registers information and replays intact. But now, researchers are discovering that memory is far more malleable, always being written and rewritten, not just by us but by others. We are discovering the precise mechanisms that can explain and even control our memories. The question is— are we ready?

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

The use of embryonic stem cells has ignited fierce debate across the spiritual and political spectrum. But what if we could create manmade stem cells - or find super cells in adults that could forever replace embryonic cells and remove the controversy? Today, we are on the brink of a new era - an age where we may be able to cure our bodies of any illness. Stephen Hawking has spent his life exploring the mysteries of the cosmos, now there is another universe that fascinates him - the one hidden inside our bodies - our own personal galaxies of cells." Hawking takes us on a fascinating journey exploring what these wondrous and baffling mechanisms are capable of. He is joined by the scientists who are on the front lines of discovery in this field including Dr. Doris Taylor who is customizing a donor's heart with the recipient's stem cells - her goal is to revolutionize heart transplants, Dr. Paul Lu and Dr. Mark Tuszynski may have created a breakthrough that could cure paralysis, and Dr. Vincent Giampapa who believes that stem cells can be used to stem the tide of aging and create a fountain of youth.

Richard Dawkins deals with some of the philosophical and social ramifications of the theory of evolution. Dawkins starts out in Kenya, speaking with palaeontologist Richard Leakey. He then visits Christ is the Answer Ministries, Kenya's largest Pentecostal church, to interview Bishop Bonifes Adoyo. Adoyo has led the movement to press Kenya's national museum to sideline its collection of hominid bones pointing to man's evolution from ape to human.[5] The collection includes the Turkana Boy discovered by Kamoya Kimeu, a member of a team led by Richard Leakey in 1984. Dawkins discusses social darwinism and eugenics, explaining how these are not versions of natural selection, and that 'Darwin has been wrongly tainted'. He then meets with evolutionary psychologist Steven Pinker to discuss how morals can be compatible with natural selection. He goes on to explaining sexual selection, with peafowls as an example. To find out whether sexual selection plays a role for altruism and kindness among humans, he visits women who are looking for sperm donors, as well as a sperm bank manager. Dawkins also explains kin selection and selfish genes.