Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

Forget the Big Bang. The real moment of creation was the Cosmic Dawn - the moment of first light. It's the moment the first stars were born, the moment that lit up the Universe, and made the first structure and the first ingredients of life. This is the scientific version of the story of Genesis. The Big Bang gets all the credit for creating our universe. But in fact, the universe it gave was dark and boring. There were no stars, no galaxies, just a vast, black fog of gas - the cosmic dark ages". But, after a hundred million years of nothing, came a dramatic moment of transformation - the Cosmic Dawn. Astronomers are now trying to witness this cosmic dawn. For the first time they have the tools to explore the very first stars of the universe and to tell the scientific story of our creation.

Professor Jim Al-Khalili continues his investigation of the atom by looking at radioactivity, the Atom Bomb and the Big Bang, and even why we are here and how we were made. He shows that, in the quest to understand the atom, the mystery of how the entire universe was created became revealed

Stephen Hawking is the most famous scientist on the planet. But behind the public face lies an argument that has been raging for almost 30 years. Has he been wrong for the last 30 years? Hawking shot to fame in the world of physics when he provided a mathematical proof for the Big Bang theory. This theory showed that the entire universe exploded from a singularity, an infinitely small point with infinite density and infinite gravity. Hawking was able to come to his proof using mathematical techniques that had been developed by Roger Penrose. These techniques were however developed to deal not with the beginning of the Universe but with black holes". Science had long predicted that if a sufficiently large star collapsed at the end of its life, all the matter left in the star would be crushed into an infinitely small point with infinite gravity and infinite density – a singularity. Hawking realised that the Universe was, in effect, a black hole in reverse. Instead of matter being crushed into a singularity, the Universe began when a singularity expanded to form everything we see around us today, from stars to planets to people. Hawking realised that to come to a complete understanding of the Universe he would have to unravel the mysteries of the black hole and its paradoxes

Our galaxy is one of hundreds of billions in the universe. View of universe through the Hubble telescope and go back almost all the way to the Big Bang.

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.