Washington, D.C. is in many ways a city of extremes. Starland Vocal Band, Marvin Gaye, Duke Ellington, Nils Lofgren, Chuck Brown, Henry Rollins, Fugazi and Trouble Funk all hail from D.C. In the early '70s, the music style go-go originated here, and has remained a local craze ever since. Dave Grohl sits down with Trouble Funk's Big Tony Fisher to talk about go-go, and explores its origins with Chuck Brown, the genre's undisputed godfather.
He also chats with Don Zientara, owner of Inner Ear Studios, which the Virginia-raised Grohl says 'produced the entire soundtrack of my youth,' as well as with members of the harDCore band Bad Brains and Ian MacKaye of Teen Idles, Minor Threat and Fugazi, who all recorded at Inner Ear over the decades. The song 'The Feast and the Famine' is recorded during this episode.

Dave Grohl discusses New Orleans' unique music history with Dr. John, Allen Toussaint and Cyril Neville. The band records in Preservation Hall and also performs with the Preservation Hall Jazz Band. The song 'In the Clear' is recorded during this episode.

Foo Fighters prepare to record at the Austin City Limits Studio, with blues guitarist Gary Clark, Jr. In this episode is examined the roots of Austin's music scene, with interviews featuring Billy Gibbons from ZZ Top, and Roky Erickson from 13th Floor Elevators, who is considered one of the American fathers of psychedelic rock. Dave also chats with Terry Lickona, the executive producer of Austin City Limits. The song 'What Did I Do? / God As My Witness' is recorded during this chapter.

Dave Grohl returns to his musical roots, while the Foo Fighters prepare to record at Seattle's Robert Lang Studio with Death Cab for Cutie's Benjamin Gibbard. Dave sets his focus on the Seattle music scene, mainly the grunge movement and its implications in American Rock Music. Interviews with Chris Cornell, Nancy Wilson, Bruce Pavitt.

The 80s was also an age of innovators and icons, of style and substance. In this chapter, Dylan Jones celebrates some of the stars who created the timeless legacy of the 1980s. From stellar BBC archive performances from the likes of Madonna, Depeche Mode, Sade, Duran Duran, Pet Shop Boys and Tina Turner to iconic MTV-era gems from Billy Idol, Eurythmics, U2, Janet Jackson, Prince and many more.
It also features rarely seen archive television footage from the BBC vaults, including Terry Wogan interviewing Grace Jones, Bruce Springsteen on the Old Grey Whistle Test and Adam Ant performing his own stunts in a behind-the-scenes look at the making of the Prince Charming video.

The 1980s was a time when artists in both the UK and US were delivering powerful social commentary in their songs. Dylan Jones selects some of the finest alternative voices from this era. From The Cure on Top of the Pops at the beginning of the decade to The Stone Roses' debut TV performance in 1989, this episode takes a comprehensive look at the alternative music of an entire era. It also features powerful live performances from Billy Bragg, Tracy Chapman, Bronski Beat and The Selecter. In addition, there are archival gems from Pixies, The Smiths, Suzanne Vega, The Fall, REM and many more.