This episode explores how scientists delved ever deeper into the world of the cell, seeking to reveal the magic ingredient that can spark a bundle of chemicals into life. Their discoveries have brought us to the brink of being able to create life for ourselves.

Physicist Jim Al-Khalili travels through Syria, Iran, Tunisia and Spain to tell the story of the great leap in scientific knowledge that took place in the Islamic world between the 8th and 14th centuries. Its legacy is tangible, with terms like algebra, algorithm and alkali all being Arabic in origin and at the very heart of modern science - there would be no modern mathematics or physics without algebra, no computers without algorithms and no chemistry without alkalis. For Baghdad-born Al-Khalili, this is also a personal journey, and on his travels he uncovers a diverse and outward-looking culture, fascinated by learning and obsessed with science. From the great mathematician Al-Khwarizmi, who did much to establish the mathematical tradition we now know as algebra, to Ibn Sina, a pioneer of early medicine whose Canon of Medicine was still in use as recently as the 19th century, Al-Khalili pieces together a remarkable story of the often-overlooked achievements of the early medieval Islamic scientists.

In part two, Professor Al-Khalili looks at the 19th century chemists who struggled to impose an order on the apparently random world of the elements. From working out how many there were to discovering their unique relationships with each other, the early scientists' bid to decode the hidden order of the elements was driven by false starts and bitter disputes. But ultimately the quest would lead to one of chemistry's most beautiful intellectual creations - the periodic table.

In the final part, Professor Al-Khalili uncovers tales of success and heartache in the story of chemists' battle to control and combine the elements, and build our modern world. He reveals the dramatic breakthroughs which harnessed their might to release almost unimaginable power, and he journeys to the centre of modern day alchemy, where scientists are attempting to command the extreme forces of nature and create brand new elements.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

In this series, David Pogue explores the fantastic chemistry behind the everyday and sets out on a worldwide quest to find the key molecules and chemical reactions that have paved the way for human civilization, life, and even the universe as we know it.
In the first episode, glass so strong you can jump on it, rubber so tough it protects a clay pot dropped from 50 feet, endless varieties of plastic. Scientists and engineers have created virtually indestructible versions of common materials by manipulating the chains of interlocking atoms that give them strength—but have they made them too tough?