The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

As the journey continues, there's beauty and danger in equal measure for Charley Boorman and Ewan McGrego. The duo ride their electric Harleys through the exotic and breathtaking Bolivian countryside in a tough ascent. The sixth episode showcases some of the challenges the hosts and the crew face when they scale the terrain. One of the Rivians runs into trouble while sandy roads and a heavy breeze sees Boorman take a tumble. Apart from all the accidents, the chapter also shows some quality work done by UNICEF when it comes to educating and working with the children in Bolivia.
The altitude sickness hits Taylor, their logistics man real bad and McGregor starts feeling it as well. The episode ends with a doctor heading to his hotel room to check up on him.

The episode opens with Ewan McGregor and Charley Boorman riding through the sleek streets of Guanacaste, Costa Rica. To add to the excitement, the show also introduces us to Ewan's daughter, Jamyan, and the father-daughter duo are lovable to watch. The audience also gets a chance to see the Masaya volcano up close. The red lava is breathtaking and scary at the same time.

As the journey continues, there's beauty and danger in equal measure. Charley and Ewan travel through the extraordinary Bolivian desert, but the sandy roads make all more difficult. The duo ride their electric bikes through the exotic and breathtaking countryside and all the way making a challenging ascent. The riders stay in a hotel made entirely out of salt before heading to La Paz. 'Bolivia' also shows some quality work done by UNICEF when it comes to educating and working with the children. McGregor and Boorman spend time with the kids before resuming their journey and ending with a ferry ride over lake Titicaca.

Ewan and Charley swap their e-Harley Davidsons for plane first and follow it up with a journey by ship to Panama. McGregor's bike needs some repairs and will be fixed by the time they reach Costa Rica. The ship they travel in with the bikes looks like a beaten-down vessel that raises genuine concerns about making the journey in one piece. The boat crew looks sharp and proactive while trying to make the show crew's journey as comfortable and safe as possible. The episode also introduces Nuqui, one of the wettest regions in the world where the ship quickly makes a pitstop to fuel up on essential supplies.

Ewan McGregor and Charley Bormann are very close to finishing their journey. Discussions on security are still on the agenda; they cannot travel at night due to dangerous cartels. They will need to do many miles on a bus with space for the bikes inside. The team manage to get the bikes on after concerns they wouldn’t fit. Repairing and conditioning the bus is an achievement considering they did it in a few days.
Ewan and Charley get back on their bikes, and they head to their last border cross to enter the United States. After 12 hours in the border, the crew, Ewan and Charley make it to America. It’s an easy stretch to L.A. on their bikes. Ewan, the crew and family, finish the last leg. It’s done, they’ve managed to finish Long Way Up. It’s such an achievement. Episode 11 is a heartfelt finale, showcasing the end of an incredible journey from both Ewan, Charley, and the team that supported them.