Hear firsthand from individuals struggling with addiction and follow the cutting-edge work of doctors and scientists as they investigate why addiction is not a moral failing, but a chronic, treatable medical condition. Easy access to drugs like heroin, fentanyl, and even prescription medications like OxyContin has fueled an epidemic of addiction - the deadliest in US history. Now, science is revealing how addiction affects the brain, and top experts are gathering evidence about how we should address our drug problem, from embracing evidence-based treatments, to rethinking public policies.

Painted over five centuries ago, Filippo Lippi's nativity is like none other: it shows the birth of Christ in a dark, wooded wilderness. There are no shepherds, kings, ox, ass – there is no Joseph. Its beauty inspired Michelangelo, Leonardo da Vinci and Botticelli. But it also conceals a deeply personal story. It was painted for Cosimo de Medici, a wealthy banker who feared that his money was dragging him straight to hell. The artist's life was equally surprising. One of the most celebrated painters of his day, Filippo Lippi was also a Carmelite friar, but he was no stranger to the temptations of the flesh, to which he frequently yielded. Shortly before painting his Adoration, he caused uproar by seducing a twenty year-old nun. His paintings rejoice not only in divine beauty, but in the beauty of women. In later times, the Adoration's history was interwoven with that of rulers and dictators. It became a bargaining chip after Napoleon's allies seized twenty merchant ships. And in the 20th century, it was hidden by the Nazis in a potassium mine, where specialist american officers, known as Monuments Men, stumbled upon it. they were now told to get it ready to be shipped out. In an unprecedented turn of events they refused. This is the only known case in the whole of the Second World War of American officers refusing an order. It was sent to the National Gallery of Art, but in 1949 Lippi's Adoration was returned to Germany.

David Attenborough narrates the intimate story of a leopard mother and her two cubs. This very special family must survive in the wilds of Botswana alongside some less-than-friendly neighbours: lions, wild dogs and hyenas. The competition for food is tough, and if they are going to make it they must learn a new skill - they must learn to fish. This is an epic family drama. With them every step of the way is local cameraman Brad Bestelink. Brad's 18-month journey following the lives of these secretive big cats offers a rare glimpse into an otherwise hidden world.

Sir David Attenborough takes a breath-taking journey through the vast and diverse continent of Africa as it's never been seen before. From the richness of the Cape of Good Hope to blizzards in the high Atlas Mountains, from the brooding jungles of the Congo to the steaming swamps and misty savannahs, Africa explores the whole continent. An astonishing array of previously unknown places are revealed along with bizarre new creatures and extraordinary behaviours. Using the latest in filming technology including remote HD cameras, BBC One takes an animal's eye view of the action. The journey begins in the Kalahari, Africa's ancient southwest corner, where two extraordinary deserts sit side by side and even the most familiar of its creatures have developed ingenious survival techniques. Black rhinos reveal a lighter side to their character as they gather around a secret waterhole. Springbok celebrate the arrival of rains with a display of 'pronking'. Bull desert giraffes endure ferocious battles for territory in a dry river bed.

Andrew Marr tells the story of the first empires which laid the foundations for the modern world. From the Assyrians to Alexander the Great, conquerors rampaged across the Middle East and vicious wars were fought all the way from China to the Mediterranean. But this time of chaos and destruction also brought enormous progress and inspired human development. In the Middle East, the Phoenicians invented the alphabet, and one of the most powerful ideas in world history emerged: the belief in just one God. In India, the Buddha offered a radical alternative to empire building - a way of living that had no place for violence or hierarchy and was open to everyone. Great thinkers from Socrates to Confucius proposed new ideas about how to rule more wisely and live in a better society. And in Greece, democracy was born - the greatest political experiment of all. But within just a few years, its future would be under threat from invasion by an empire in the east...

Lucy Worsley continues her journey through Russia in the footsteps of the Romanovs, the most powerful royal dynasty in modern European history. In this episode she examines the extraordinary reign of Catherine the Great, and the traumatic conflict with napoleonic France that provides the setting for the novel War and Peace. At the magnificent palace of Peterhof near St Petersburg, Lucy charts the meteoric rise of Catherine the Great, who seized the Russian throne from her husband Peter III in 1762 and became the most powerful woman in the world. Catherine was a woman of huge passions - for art, for her adopted country (she was German by birth) and for her many lovers.
Catherine expanded her empire through military victories overseas, while at home she encouraged education and introduced smallpox inoculation to Russia. But Catherine struggled to introduce deeper reforms, and the institution of serfdom remained largely unchanged. Lucy explains how this injustice fuelled a violent rebellion. Nevertheless, Catherine left Russia more powerful on the world stage than ever. But all she had achieved looked set to be undone when Napoleon invaded Russia in 1812. Lucy relives the pivotal battle of Borodino, when the Russian army finally confronted the French forces; the traumatic destruction of Moscow; and, under Catherine's grandson Alexander, the eventual victory over the French that provided the Romanov dynasty with its most glorious hour.