The series explores the impact of racism on a global scale and chronicles the shifts in the perception of race and the history of racism in Europe, the Americas, Australia and Asia. The first episode begins by assessing the implications of the relationship between Europe, Africa and the Americas in the 15th century. It considers how racist ideas and practices developed in key religious and secular institutions, and how they showed up in writings by European philosophers Aristotle and Immanuel Kant.

The Bronze Age covers 2,000 years of history in the Aegean/Mediterranean, Egypt and Near East from roughly 3000 BC to 1000 BC. New animations produced by Pixeldust include the reconstruction of four ancient capitals, including the Egyptian city of Thebes and the early Greek capital of Mycenae. What singled out this period and the new societies and cities that emerged? The development of formal writing is one among several important factors.

The story of Nikola Tesla, the great scientist, visionary, and inventor who gave the world alternating current electricity, as well as being the father of radio. The film tells the story of this man's astonishing genius, his visions and inventions. Tesla's own scientific and autobiographical writings, as well as archival photographs and re-enactments are used to tell the story. A native of Austro-Hungary, Tesla came to America in 1884. Working first with Edison, the two inventors fell out over Edison's insistence on using direct current. Tesla took his alternating current vision to Westinghouse. Tesla worked to unlock the secrets of energy and electricity. The film follows Tesla's exploits and eccentricities, which made him a darling of the press. Largely forgotten today in spite of the great debt the modern world owes him, the film pays tribute to this overlooked genius

The rock revolution of the 1960s seen through the life and music of Jimi Hendrix. We see how he became the first, ultimately doomed, icon of rock. The Birth Of Rock also explores the influence of rhythm & blues on a generation of British musicians such as The Rolling Stones, Cream and The Who, and how the song-writing of Bob Dylan and studio developments of The Beatles transformed the possibilities and ambitions of rock.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

In the final episode, we hear how employees on the 17th floor were rewarded, and we see Madoff's $65 billion Ponzi scheme quickly collapses as investors begin to withdraw their money during the 2008 Financial Crisis. We see how Madoff's sons attempt to stop their father from writing bonus cheques for long-time investors, faithful employees, and extended family to help cushion the blow. Madoff confesses to the Ponzi scheme, and the FBI arrests him.
After pleading guilty, Madoff is sentenced to 150 years in prison. Two years after learning of the Ponzi scheme, his eldest son Mark is found hanging from a pipe, dead of an apparent suicide. His other son dies of lymphoma six years later.