The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

In the third episode of the series, Morgan Freeman examines different faiths' concepts of God, discovering how monotheism began in Egypt and Israel and allowing a neuroscientist to examine his own brain.

In the fifth episode of the series, Morgan Freeman sets to examine the nature of evil, visiting a serial killer in prison and witnessing an exorcism in India. He also explores ancient beliefs, including Zoroastrianism.

Humanity’s potential seems limitless. But could we become as powerful as God? Scientific breakthroughs grant our species seemingly divine abilities. Biologists tinkering with DNA are figuring out ways to grow new life forms, while neuroscientists try to create artificial consciousness. Statisticians around the world are using big data to predict the future and computer scientists have discovered a "God algorithm" that could solve any global problem in an instant. But to truly become God, we not only have to be all knowing, but all being. Quantum physicists are figuring out how to teleport matter at the speed of light!