A ground-breaking new trial at Imperial College London sees, for the first time ever under controlled conditions, a psychedelic drug tested head-to-head against a standard antidepressant as a treatment for depression. The film follows a pioneering team of scientists and psychotherapists as they compare the effects of psilocybin (the active ingredient of magic mushrooms) with an antidepressant on a small group of participants with clinical depression.
This is scientific research at its most cutting edge. With over seven million people being prescribed antidepressants each year in England alone, this drug trial is an important milestone in understanding a completely different treatment for depression. How do psychedelic drugs measure up against the industry-standard antidepressants that have been popular since the 1990s? The empirical results of the trial are explored alongside the participants’ powerful lived experience.

Gaby Roslin and Amir Khan present a program in which they apply the latest science to some of the worst sleepers. They include an extreme snorer, a man who suffers from night terrors, a woman who has restless leg syndrome, and a man with chronic insomnia for 20 years.
The film also shows a sleep deprivation experiment to test for risky behaviour, pain resistance and emotional control. When the subjects reach the final hours of the challenge, the experiment begins to take its toll as the participants' emotions go into overdrive, with one threatening to quit altogether.

Western countries are the most sleep-deprived countries in the world. Insomniac Michael Mosley finds out what happens if we don't get enough sleep and looks at surprising solutions to help us get more.

The extraordinary inside story of the biggest scientific challenge of our age – following a small band of vaccine scientists around the world who took on Covid-19 and ultimately delivered the weapon to beat it.
As news of the coronavirus broke around the globe, a small group of scientists jumped into action to tackle one of the greatest medical challenges of our time: to create a vaccine against a virus no-one had ever seen before and to do so in record time, all during a deadly, global pandemic.

Trauma is the invisible force that shapes our lives. It shapes the way we live, the way we love and the way we make sense of the world. It is the root of our deepest wounds. Dr. Maté gives us a new vision: a trauma-informed society in which parents, teachers, physicians, policy-makers and legal personnel are not concerned with fixing behaviors, making diagnoses, suppressing symptoms and judging, but seek instead to understand the sources from which troubling behaviors and diseases spring in the wounded human soul.
The interconnected epidemics of anxiety, chronic illness and substance abuse are, according to Dr Gabor Maté, normal. But not in the way you might think. One in five Americans are diagnosed with mental illness in any given year. Suicide is the second most common cause of death in the US for youth aged 15-24, and kills over 700,000 people a year globally and 48,300 in the USA . Drug overdose kills 81,000 in the USA annually. The autoimmunity epidemic affects 24 million people in the USA. What is going on?
“So much of what we call abnormality in this culture is actually normal responses to an abnormal culture. The abnormality does not reside in the pathology of individuals, but in the very culture that drives people into suffering and dysfunction.” — Gabor Maté

Of all the wonders of the human body, there's one more mysterious than any other. Blood: five precious litres that keep us alive. Yet how much do we really know about this sticky red substance and its mysterious, life-giving force? Michael Mosley gives up a fifth of his own blood to perform six bold experiments". From starving it of oxygen to injecting it with snake venom, Michael reveals the extraordinary abilities of blood to adapt and keep us alive. Using specialist photography, the programme reveals the beauty in a single drop. Michael even discovers how it tastes when, in a television first, he prepares a black pudding with his own blood. Down the ages, our understanding of blood has been as much myth as science, but Michael reveals there might be truth in the old vampire legends, as he meets one of the scientists behind the latest research that shows young blood might be able to reverse the ageing process - the holy grail of modern medicine.