Tony Accardo receives a phone call from Joseph P. Kennedy, asking the mob kingpins to use their pull with the Illinois union vote to help his son, John F. Kennedy, win the upcoming presidential election. In return, he offers to put an end to his son Robert F. Kennedy's investigation into Giancana and the Outfit. As election day nears, Kennedy's fight against Richard Nixon tightens, turning Illinois into a key battleground. Giancana delivers the union votes. After a close race, Kennedy is declared the victor. Just weeks after Kennedy takes office, his brother Robert is named Attorney General. To the Chicago mob's surprise, when Robert takes office as the new U.S. Attorney General in 1961, he makes his top priority going after organized crime ó and one of his primary targets is the Outfit. Weeks after, John F. Kennedy is shot and killed in Dallas. After his brother is assassinated, Robert steps down from his post as Attorney General and the investigation into organized crime is virtually dropped. The government begins an investigation into the assassination, with rumors already circulating that the mafia could have been involved.

Stone opens the episode on Vietnam with a review of American intervention in Latin America. Lyndon Johnson, according to Stone, disregarded JFK’s “memo” about withdrawing troops and instead escalated. The Cataclysm in Vietnam as the war reaches a turning point - there's no going back. The betrayal by Richard Nixon.

Troop withdrawals begin as the Americans train their ARVN allies to take over the war. Gery Benedetti patrols the hostile waters of the Mekong Delta. James Anderson leads a battalion into Cambodia after Nixon's controversial order. Don DeVore struggles to survive a fierce night attack, and Anne Purcell gets promising news about her husband.