Documentary which tells the story of the theory of evolution by natural selection which is now scientific orthodoxy, but when it was unveiled it caused a storm of controversy. Many people criticised it for being short on evidence and long on assertion and Darwin, being the honest scientist that he was, agreed with them. He entrusted future generations to complete his work and prove the essential truth of his vision. Evolutionary biologist Professor Armand Marie Leroi argues that, with the new science of evolutionary developmental biology (evo devo), it may be possible to take that theory to a new level - to do more than explain what has evolved in the past, and start to predict what might evolve in the future.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Richard Dawkins deals with some of the philosophical and social ramifications of the theory of evolution. Dawkins starts out in Kenya, speaking with palaeontologist Richard Leakey. He then visits Christ is the Answer Ministries, Kenya's largest Pentecostal church, to interview Bishop Bonifes Adoyo. Adoyo has led the movement to press Kenya's national museum to sideline its collection of hominid bones pointing to man's evolution from ape to human.[5] The collection includes the Turkana Boy discovered by Kamoya Kimeu, a member of a team led by Richard Leakey in 1984. Dawkins discusses social darwinism and eugenics, explaining how these are not versions of natural selection, and that 'Darwin has been wrongly tainted'. He then meets with evolutionary psychologist Steven Pinker to discuss how morals can be compatible with natural selection. He goes on to explaining sexual selection, with peafowls as an example. To find out whether sexual selection plays a role for altruism and kindness among humans, he visits women who are looking for sperm donors, as well as a sperm bank manager. Dawkins also explains kin selection and selfish genes.

The terrorist group Boko Haram is responsible for thousands of deaths in Nigeria. Now, the government is determined to drive these militants from the country. But is the hunt for insurgents causing as much harm as it's preventing? Former Navy SEAL and new VICE correspondent Kaj Larsen travels to Nigeria to see what this cat-and-mouse game means for the people caught in the middle of the fight. 'Unnatural Selection': For centuries, scientists have been working to change the genetic traits of plants and animals. Now, the new gene-editing method CRISPR has made that process astonishingly simple - so simple it could easily be used on humans. Isobel Yeung reports from Brazil, Scotland, China and the U.S. on the technological advances that could reshape evolution as we know it.

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.