Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring the intense effects of its Psilocybin and its potential therapeutic use.
In the second episode, we are introduced to Ben, who’s battled with crippling Obsessive-Compulsive Disorder (OCD) his entire life. When he had his firstborn, Ben’s life became full of panic attacks regarding his son’s safety, and he knew something had to change. Ben signed up for a psilocybin-assisted therapy clinical trial which was testing whether the psychedelic could help people with severe OCD. In the session under the influence of psilocybin, Ben felt decomposed and eventually grew into a tree. While living as a tree, he saw his human self, playing with his child. Though this sounds scary, from Ben’s perspective, it was beautiful. He was one with the universe, seeing himself in the ultimate third-person perspective. Finally, he saw how it could be different if he didn’t let his OCD control him. And several months out, all the symptoms disappeared.
Ben’s story is one of many told in this series, which gives hope that help is right around the corner for the millions who suffer —often in silence— with debilitating mental disorders. But Michael Pollan’s work is showcasing the success stories. Often, even in the most successful trials, psychedelic-assisted therapy only helps up to a third of people enter remission. More frequently, patients are helped —sometimes substantially— but they still suffer with their illnesses and some people aren’t helped at all.

Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to become legalized, thanks to passionate advocates.
The episode about 3,4-Methylenedioxymethamphetamine (MDMA), is focused on Multidisciplinary Association for Psychedelic Studies (MAPS) clinical trials treating Post-traumatic stress disorder (PTSD).

Phil Stutz is one of the world's leading psychiatrists. He's helped countless patients over 40 years, including world-class creatives and business leaders, and among them many therapy-skeptics. Directed by friend and patient Jonah Hill, the film explores Stutz's life and walks the viewer through his signature visualization exercises, ‘The Tools’. As Hill sits down with Stutz for an unorthodox session that flips their typical doctor-patient dynamic, they bring The Tools to life in a humorous, vulnerable and ultimately therapeutic experience.
Featuring candid discussion of both Stutz's and Hill's personal mental health journeys, alongside the lighthearted banter of two friends from different generations, the film beautifully frames The Tools and the journey toward mental health in a manner that's accessible to anyone whether or not they are actively seeking help.

In the second part and conclusion, a spotlight on the mass marketing of the synthetic opioid fentanyl examines the connections between drug manufacturers and government policy. Video of sales retreats and promotional material reveals a deep cynicism among company employees and a disregard for the widespread, nefarious corporate practices.

A ground-breaking new trial at Imperial College London sees, for the first time ever under controlled conditions, a psychedelic drug tested head-to-head against a standard antidepressant as a treatment for depression. The film follows a pioneering team of scientists and psychotherapists as they compare the effects of psilocybin (the active ingredient of magic mushrooms) with an antidepressant on a small group of participants with clinical depression.
This is scientific research at its most cutting edge. With over seven million people being prescribed antidepressants each year in England alone, this drug trial is an important milestone in understanding a completely different treatment for depression. How do psychedelic drugs measure up against the industry-standard antidepressants that have been popular since the 1990s? The empirical results of the trial are explored alongside the participants’ powerful lived experience.

Dr George McGavin and Dr Zoe Laughlin set up base camp at one of the UK's biggest sewage works to investigate the revolutionary science finding vital renewable resources and undiscovered life in human waste.
Teaming up with world-class scientists, they search for biological entities in sewage with potentially lifesaving medical properties, find out how pee can generate electricity, how gas from poo can fuel a car and how nutrients in waste can help solve the soil crisis. They follow each stage of the sewage treatment process, revealing what the stuff we flush can tell us about how we live today, and the mind boggling biotechnology being harnessed to clean it, making the wastewater safe enough to return to the environment.