Where will loved ones spend their last days? Who will be in the room? What feelings and secrets need to be shared with family before it is too late? Acclaimed filmmakers Rob Epstein and Jeffrey Friedman probe these questions and more in the context of two San Francisco Bay Area medical facilities on the forefront of creating new paradigms for end of life decisions with grace.
Filmed and edited in intimate vérité style, 'End Game' follows visionary medical practitioners who are working on the cutting edge of life and death and are dedicated to changing our thinking about both.

Someday, I will die. But should I? If I was offered a longer life, I would take that in a second. But how long is too long? Is death something I should deny forever, or is death and the role it plays in the universe something I am better off accepting?

Gaby Roslin and Amir Khan present a program in which they apply the latest science to some of the worst sleepers. They include an extreme snorer, a man who suffers from night terrors, a woman who has restless leg syndrome, and a man with chronic insomnia for 20 years.
The film also shows a sleep deprivation experiment to test for risky behaviour, pain resistance and emotional control. When the subjects reach the final hours of the challenge, the experiment begins to take its toll as the participants' emotions go into overdrive, with one threatening to quit altogether.

At an extraordinary moment in the history of one of the world’s oldest and most controversial drugs, Dr Javid Abdelmoneim investigates the very latest medical and scientific research into the effects of cannabis on the brain and the body, to find out whether it will help or harm patients.
Javid meets the young epilepsy patient responsible for changing the law around medicinal cannabis in the UK and sees the remarkable effects it has on his condition. He visits a medicinal cannabis farm in Denmark to learn how a company known for growing the recreational drug are now producing medicinal cannabis to be exported all over Europe. He travels to Israel, to find out why they have been using cannabis as a medicine for over 20 years and meets the scientists studying the safety and effectiveness of cannabis in treating pain. And he meets the so-called godfather of cannabis, who at 88 years old is still an active research scientist and considered the world’s leading cannabis expert.

The Spirit Molecule investigates dimethyltryptamine (DMT), a naturally occurring psychoactive compound, which exists in humans, and potentially every living organism. Utilizing Dr. Rick Strassman's government-sanctioned, human DMT research as the documentary's backbone, the study's potential impact and its inconceivable revelations emerge. A closer examination of DMT's effects through two traditionally opposed concepts, science and spirituality, The Spirit Molecule unravels the connections between cutting-edge neuroscience, quantum mechanics and human spirituality.
The Spirit Molecule, a simple molecule with enormous implications. The subtle combination of science, spirituality, and philosophy results in an abundance of incredible ideas and theories that could alter the way we understand the nature of reality and our relationship to it.

Heart disease is the number one cause of deaths worldwide, killing more than eight million people each year. Cardiac infarction, more commonly known as a heart attack, can happen without warning, killing heart muscle cells immediately. Even if the patient recovers, the damage to their heart may not.
But there are researchers frantically working to change that. Meet the people inventing the future of cardiac health, from new ways of imaging the body, to the possibility of 3D printing a functioning heart.