The episode opens with Ewan McGregor and Charley Boorman riding through the sleek streets of Guanacaste, Costa Rica. To add to the excitement, the show also introduces us to Ewan's daughter, Jamyan, and the father-daughter duo are lovable to watch. The audience also gets a chance to see the Masaya volcano up close. The red lava is breathtaking and scary at the same time.

Widespread immigration to the U.S. from Latin countries begins – first with a small group from Cuba, then a larger one from Mexico. Both flee chaos and violence in their home country and are attracted by opportunities in the United States. In 1898, the U.S. helps liberate Cuba and Puerto Rico from Spain but then seizes Puerto Rico as its colony. The first Puerto Rican arrivals (now U.S. citizens) establish a network in New York.

Hector Berrellez identifies the mysterious Cuban who interrogated Kiki Camarena: a veteran CIA operative, Felix Rodriguez, a key figure in the Iran-Contra scandal. Although warned not to take his investigation further, Hector refuses and is eventually forced into retirement. The case languishes for years, and then a new source comes forward with a shocking allegation.

Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring the intense effects of its Psilocybin and its potential therapeutic use.
In the second episode, we are introduced to Ben, who’s battled with crippling Obsessive-Compulsive Disorder (OCD) his entire life. When he had his firstborn, Ben’s life became full of panic attacks regarding his son’s safety, and he knew something had to change. Ben signed up for a psilocybin-assisted therapy clinical trial which was testing whether the psychedelic could help people with severe OCD. In the session under the influence of psilocybin, Ben felt decomposed and eventually grew into a tree. While living as a tree, he saw his human self, playing with his child. Though this sounds scary, from Ben’s perspective, it was beautiful. He was one with the universe, seeing himself in the ultimate third-person perspective. Finally, he saw how it could be different if he didn’t let his OCD control him. And several months out, all the symptoms disappeared.
Ben’s story is one of many told in this series, which gives hope that help is right around the corner for the millions who suffer —often in silence— with debilitating mental disorders. But Michael Pollan’s work is showcasing the success stories. Often, even in the most successful trials, psychedelic-assisted therapy only helps up to a third of people enter remission. More frequently, patients are helped —sometimes substantially— but they still suffer with their illnesses and some people aren’t helped at all.

(Click CC for subtitles) After Kiki's murder, Hector gets reassigned to Mexico where he ends up leading DEA agents and Mexican soldiers into the longest and deadliest shootout in DEA history. While this puts a million dollar bounty on his head, it also impresses the DEA brass, who then decide to put Hector, one of their most aggressive narcs, in charge of the investigation into Kiki's murder.

(Click CC for subtitles) Hector Berrellez's informants give him ground breaking evidence - first-hand, eyewitness accounts of Kiki's kidnapping, torture, and murder. He learns the incident took place in a cartel hacienda where high-level Mexican government officials were present, along with a mysterious Cuban. They also reveal the cartel and governments attempts to cover up the crime.