The film explores George Mallory's obsession with becoming the first person to reach the highest place on Earth. Told through the explorer's poignant and evocative letters to his wife, Ruth, previously unseen photos and film archive from 1924 (restored from the original nitrate especially for the film), dramatization and a modern-day expedition retracing the original route taken in 1924, Mallory's incredible adventure lives again. The expedition was led by renowned mountaineer Conrad Anker, whose life became inextricably linked with Mallory after he found Mallory s body on Everest in 1999. Using replica 1920s-era clothing and equipment, Anker sets out to solve the great mystery of whether Mallory succeeded in summiting Everest before he died he was last seen just 800 feet from the summit before the clouds closed in and he disappeared into legend. The most heart-breaking clue: All of Mallory's belongings were found intact on his body, except the photograph of his beloved Ruth, which he promised to leave at the top of the world if he succeeded.

The journeys of the Voyager probes is put in the context of the Netherlands in the seventeenth century, with a centuries-long tradition of sailing ship explorers, and its contemporary thinkers (such as Constantijn Huygens and his son Christian). Their discoveries are compared to the Voyager probes' discoveries among the Jovian and Saturn systems. In Cosmos Update, image processing reconstructs Voyager’s worlds and Voyager’s last portrait of the Solar System as it leaves is shown.

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.