The tour was designed by Willie Williams, who has worked on every U2 tour since 1982. Williams had been toying with ideas for 360-degree stadium staging for U2 for a number of years, and presented sketches of a four-legged design to the group near the end of their Vertigo Tour in 2006. The inspiration for the 'spaceship-on-four-legs' design, nicknamed 'the Claw', came from the landmark Theme Building at Los Angeles International Airport.

Horizon investigates the idea that the best way to lose weight successfully is a personalised approach, diets tailored to our individual biology and psychology. In a groundbreaking experiment, Dr Chris van Tulleken and Tanya Byron join a team of experts to put 75 overweight volunteers on diets designed to tackle the specific reasons why they eat too much. The volunteers are put through a series of tests at a residential clinic to understand how their genes, hormones and psychology influence their eating behaviour. They are then put on the diets the experts believe are best suited to them. Can science succeed where other diets have failed?

Rockefeller, Carnegie and Morgan team up to help elect William McKinley to the U.S. presidency by paying for his 1896 campaign, to avoid a possible attack on monopolies. However, fate intervenes when McKinley is suddenly assassinated, and vice president Theodore Roosevelt assumes the presidency and promptly begins dissolving monopolies and trusts in America. Meanwhile, Morgan buys out Carnegie Steel to make Carnegie the richest man in the world, and Henry Ford designs an affordable automobile with his Model T and starts his own business, Ford Motor Company, which sets a new business model for companies to follow.