What sort of alien civilizations might exist in the vastness of space? Terra is the fictional world imagined in Episode 4, a planet nine billion years old, twice as old as Earth. Old enough that a truly advanced intelligence could evolve. It was once a fertile world, now it is barren. But life can still thrive here in artificial domes. Over time, they've evolved not to need their bodies. They exist only as neural tissue. They never age, they never die. They're monitored and maintained by robots.
If alien civilizations are statistically so likely, why haven't astronomers found any sign of them? Where is everyone? Every time we look at an individual star, that's like dropping a bucket in the ocean. We're going to have to look at a lot of stars and to search through a lot of data until we find the clue that leads us to another civilization.

Quinto sets out to discover whether aliens exist and what evidence we have to prove it. He meets with several who say they have encountered extra-terrestrial life–a man who has been abducted by aliens several times since childhood; a man who claims to have extracted an alien implant; and a woman who shows Zachary what it feels like to be abducted into a spacecraft.
Zachary also meets with the world's leading scientists at SETI in Green Banks, West Virginia. There, utilizing the world's largest telescope, they show him the methods they employ to communicate with potential other-worldly visitors and what this research has taught them about a mysterious radio signal they picked up 3 billion light years away.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.